One of the big problems I have faced by using Vista Ultimate on my primary development machines as a host OS for virtual PC development environments has been the fact that Vista Ultimate (and I am assuming other versions of Vista as well) have problems copying extremely large files. It was part of this frustration that led us to develop AngeliaSync, a folder synchronization utility which does an excellent job of maintaining synchronized folders.
If you are looking for an inexpensive and easy to use backup utility, why not give AngeliaSync a try?
http://www.kamradtandhill.com/angeliasync.asp